ceesdekker.net for Dummies
ceesdekker.net for Dummies
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Halfway by way of his job, Cees Dekker reinvented himself. Just after decades of hardcore physics, he shifted his emphasis to ‘nanobiology’ in the convert from the millennium. A expression he coined himself, as being a subject of reality.
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Like a individual, I contain the biblical assignment to discover and use almost everything in development for the good thing about my neighbour. I do not expertise any conflict amongst religion and science. Quite the opposite, my religion stimulates me to complete science, to get open up-minded on the globe.’
Nanofabrication of electrodes with sub-5 nm spacing for transport experiments on solitary molecules and metal clusters
We create point-of-treatment diagnostics take a look at of neglected tropical conditions inside of resource-constrained settings, based on Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.
Within the years following these discoveries, my investigate pursuits shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The focus of many scientists in the sector also shifted to graphene (where by, funnily more than enough, the main graphene ribbons ended up referred to as ‘nanotubes which can be Reduce open up alongside their length’) just after the invention of the two-dimensional product in 2004.
We use nanofabricated microfluidic structures to sample spatial boundaries for microbes and biomimetic vesicles with reconstituted protein networks which evaluate the basic part of spatial confinement on the molecular and cellular level. Our jobs involve the subsequent:
Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation
What if, in lieu of employing conventional top rated-down silicon electronics, transistors might be crafted from the bottom up working with single organic and natural molecules as the switching things? This idea, which grew to become The premise of right cees dekker now’s industry of molecular electronics, very first emerged during the seventies.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-producing method
‘The idea that There's this type of issue to be a beginning, a large bang, is presently an interesting signpost to take into consideration that there was a creator. But extra usually, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: basically, you will discover only atoms and purely natural forces that we can measure.
2006, 1st demonstration of molecular sorting in a lab on the chip employing biomotors; discovery of nanobubbles in good-state nanopores; and very first estimate of electrokinetic Strength conversion inside of a nanofluidic channel
Visualization of unstained DNA nanostructures with Highly developed in-focus transmission electron microscopy strategies
Good-point out nanopores have proven to be a astonishingly functional probe for one-molecule analysis of DNA. I will describe a few of our latest findings – especially DNA knots – and our endeavours to extend the abilities of stable-point out nanopores even further, in the direction of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.